Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910657 | 1.00 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2DDAH1TSHR | |
| SCHEMBL4910662 | 1.00 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2DDAH1TSHR | |
| SCHEMBL10386531 | 0.83 | ALOX15 (0.39) | HCAR2KEAP1NFE2L2TSHRHSD17B10 | |
| SCHEMBL10386530 | 0.83 | ALOX15 (0.39) | HCAR2KEAP1NFE2L2TSHRHSD17B10 | |
| SCHEMBL11471057 | 0.81 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2TSHRHSD17B10 | |
| SCHEMBL11471056 | 0.81 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2TSHRHSD17B10 | |
| SCHEMBL4807131 | 0.81 | NPSR1 (0.48) | HCAR2DDAH1HSD17B10NPSR1 | |
| SCHEMBL4807139 | 0.81 | NPSR1 (0.48) | HCAR2DDAH1HSD17B10NPSR1 | |
| SCHEMBL4675106 | 0.79 | — | — | |
| SCHEMBL13531532 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |