Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.60 |
| ▸ | HTR2C | P28335 | 10/20 | 0.60 |
| ▸ | HTR2B | P41595 | 10/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.35 |
| ▸ | HRH2 | P25021 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917201 | 0.93 | HTR2A (0.65) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL7918556 | 0.91 | HTR2A (0.69) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL7916088 | 0.89 | HTR2A (0.74) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL2335277 | 0.88 | HTR2A (0.60) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL2338157 | 0.86 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL2337901 | 0.86 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH3ALDH1A1 | |
| SCHEMBL7922016 | 0.84 | HTR2A (0.67) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL2341360 | 0.82 | HTR2A (0.82) | HTR2AHTR2CHTR2BHRH3HRH2 | |
| SCHEMBL2344701 | 0.81 | HTR2A (0.65) | HTR2AHTR2CHTR2B | |
| SCHEMBL2335407 | 0.80 | HTR2A (0.86) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053825-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-14 | — | — | WO | disclosed |