Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 2/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922027 | 0.99 | ROCK2 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL1150210 | 0.99 | ROCK2 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL7913240 | 0.94 | ROCK2 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL7903224 | 0.93 | CYP19A1 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL7911578 | 0.93 | BCL2 (0.35) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL7911557 | 0.93 | FFAR1 (0.35) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL7917118 | 0.92 | ROCK2 (0.34) | ROCK2TP53SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL7913269 | 0.90 | ROCK2 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL3209182 | 0.87 | FFAR1 (0.34) | ROCK2TP53PKMNFKB1NFKB2 | |
| SCHEMBL795594 | 0.86 | ROCK2 (0.34) | ROCK2TP53PKMNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291485-B1 | TREATMENT OF POST-PTCA RESTENOSIS | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-1002797-A1 | 4,5-DIHYDRO- 1H]-BENZ g]INDAZOLE-3-CARBOXYLIC ACID DERIVATIVES | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2000-05-24 | — | — | EP | disclosed |