Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917267 | 1.00 | RECQL (0.50) | RECQLCYP3A4CYP2C9LMNAMCL1 | |
| SCHEMBL2802060 | 0.90 | LMNA (0.51) | RECQLCYP3A4CYP2C9LMNAMCL1 | |
| SCHEMBL28332697 | 0.89 | CYP3A4 (0.53) | RECQLCYP3A4CYP2C9LMNAMCL1 | |
| SCHEMBL29263785 | 0.87 | TDP1 (0.59) | RECQLLMNAMEN1KMT2ATDP1 | |
| SCHEMBL29429676 | 0.87 | TDP1 (0.59) | RECQLLMNAMEN1KMT2ATDP1 | |
| SCHEMBL2727700 | 0.87 | TDP1 (0.59) | RECQLLMNAMEN1KMT2ATDP1 | |
| SCHEMBL9995893 | 0.85 | CYP3A4 (0.50) | RECQLCYP3A4CYP2C9LMNAMCL1 | |
| SCHEMBL3256825 | 0.85 | CYP3A4 (0.59) | RECQLCYP3A4CYP2C9LMNAMEN1 | |
| SCHEMBL1381137 | 0.85 | RECQL (0.53) | RECQLCYP3A4CYP2C9LMNAMCL1 | |
| SCHEMBL1381132 | 0.85 | RECQL (0.53) | RECQLCYP3A4CYP2C9LMNAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083894-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063994-A9 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999063994-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |