Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065009 | 0.90 | HCRTR1 (0.39) | CTSAHCRTR1HCRTR2WDR5 | |
| Hydrochloric Acid SCHEMBL4325701 | 0.89 | HCRTR1 (0.39) | MEN1KMT2ACYP1A2CYP2C19CTSA | |
| SCHEMBL8072156 | 0.82 | GRM2 (0.42) | GRM2CTSAKITFFAR1 | |
| SCHEMBL8072151 | 0.82 | CD274 (0.37) | GRM2CTSAKITFFAR1 | |
| SCHEMBL3791157 | 0.81 | PDE4D (0.45) | ADORA2AMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8070837 | 0.81 | FFAR1 (0.39) | GRM2CTSAKITFFAR1 | |
| SCHEMBL3792183 | 0.80 | PDE4D (0.42) | ADORA2AMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8066309 | 0.80 | MAP4K4 (0.42) | KIT | |
| SCHEMBL7916577 | 0.80 | PDE4D (0.41) | CTSAHCRTR1HCRTR2WDR5 | |
| SCHEMBL7913183 | 0.79 | MAPK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |