Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070837 | 0.91 | FFAR1 (0.39) | CD274KITGRM2CTSAFFAR1 | |
| SCHEMBL8072156 | 0.91 | GRM2 (0.42) | CD274KITGRM2SMN1; SMN2CTSA | |
| SCHEMBL3465800 | 0.89 | PDE4D (0.42) | CTSA | |
| SCHEMBL3466193 | 0.88 | FYN (0.40) | CD274PARP1SMN1; SMN2CTSAMAPK1 | |
| SCHEMBL3798635 | 0.86 | CTSA (0.41) | KITCTSAMAPK1 | |
| SCHEMBL8066309 | 0.85 | MAP4K4 (0.42) | KITMAPK1ABL1FLT3NTRK1 | |
| SCHEMBL7913183 | 0.82 | MAPK1 (0.41) | MAPK1ABL1 | |
| SCHEMBL7917992 | 0.82 | ADORA2A (0.38) | KITGRM2CTSAFFAR1 | |
| SCHEMBL3791661 | 0.81 | PDE4D (0.44) | CD274GRM2CTSAMAPT | |
| SCHEMBL3794094 | 0.80 | GRM2 (0.41) | GRM2SMN1; SMN2CTSAMAPK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |