Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862382 | 0.86 | FFAR1 (0.54) | MYCMCL1FFAR1FFAR4PPARG | |
| SCHEMBL629058 | 0.84 | MYC (0.50) | MYCMCL1FOLH1PPARGPPARA | |
| SCHEMBL630063 | 0.82 | MYC (0.49) | MYCMCL1FOLH1KDM4EALDH1A1 | |
| SCHEMBL6625278 | 0.82 | MYC (0.49) | MYCMCL1FOLH1KDM4EALDH1A1 | |
| SCHEMBL6626252 | 0.82 | MYC (0.49) | MYCMCL1FOLH1KDM4EALDH1A1 | |
| SCHEMBL29030199 | 0.80 | NR1H4 (0.58) | MYCHDAC7MCL1NR1H4THRB | |
| Hydrochloric Acid SCHEMBL29030208 | 0.79 | NR1H4 (0.57) | MYCHDAC7MCL1NR1H4THRB | |
| SCHEMBL7605533 | 0.78 | RAB9A (0.51) | RAB9AALDH1A1FFAR1FFAR4FNTA | |
| SCHEMBL29064695 | 0.77 | MYC (0.56) | MYCHDAC7MCL1KDM4EALDH1A1 | |
| SCHEMBL7904826 | 0.76 | FNTA (0.42) | MYCMCL1FOLH1FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |
| WO-1998050030-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |