Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 2/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918131 | 1.00 | CETP (0.48) | CETPNR1H2NR1H3KLK7STS | |
| SCHEMBL5457099 | 0.88 | ABCB1 (0.42) | CETPKLK7STSABCB1GPR119 | |
| SCHEMBL14592644 | 0.88 | ABCB1 (0.42) | CETPKLK7STSABCB1GPR119 | |
| SCHEMBL7908527 | 0.87 | CETP (0.47) | CETPNR1H2NR1H3KLK7STS | |
| SCHEMBL7908533 | 0.87 | CETP (0.47) | CETPNR1H2NR1H3KLK7STS | |
| SCHEMBL18711884 | 0.81 | CETP (0.42) | CETPNR1H2NR1H3KLK7STS | |
| SCHEMBL31642777 | 0.80 | ABCB1 (0.41) | CETPKLK7STSABCB1GPR119 | |
| SCHEMBL14592659 | 0.78 | CHRM2 (0.44) | CETPNR1H2ABCB1 | |
| SCHEMBL2433744 | 0.78 | CHRM2 (0.44) | CETPNR1H2ABCB1 | |
| SCHEMBL27379482 | 0.78 | CHRM2 (0.44) | CETPNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |