Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14117650 | 0.88 | PDE7A (0.43) | PDE7AAKR1B1TSHRTDP1CRBN | |
| SCHEMBL7927641 | 0.81 | PDE7A (0.43) | PDE7AAKR1B1TSHRTDP1CALCRL | |
| SCHEMBL23857468 | 0.81 | PDE7A (0.44) | PDE7AAKR1B1TSHRTDP1CRBN | |
| SCHEMBL409009 | 0.79 | TSHR (0.47) | PDE7AAKR1B1TSHRTDP1CALCRL | |
| SCHEMBL7917599 | 0.74 | ADRA2A (0.51) | PDE7ATSHRTDP1 | |
| SCHEMBL14117655 | 0.74 | TSHR (0.38) | PDE7AAKR1B1TSHRTDP1CALCRL | |
| SCHEMBL14117632 | 0.73 | PDE7A (0.46) | PDE7AAKR1B1TSHRTDP1CRBN | |
| SCHEMBL12229850 | 0.73 | TSHR (0.40) | PDE7AAKR1B1TSHRTDP1CALCRL | |
| SCHEMBL7928992 | 0.73 | PDE7A (0.44) | PDE7AAKR1B1TSHRTDP1CRBN | |
| SCHEMBL14117657 | 0.73 | TSHR (0.38) | PDE7AAKR1B1TSHRTDP1CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |