Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918181 | 0.91 | PDE4D (0.46) | PDE4DFFAR1FBP1SNCAPDE4B | |
| SCHEMBL3790847 | 0.85 | PDE4D (0.68) | PDE4DFBP1SNCAPDE4BALDH1A1 | |
| SCHEMBL4326850 | 0.85 | TAAR1 (0.47) | PDE4DSNCAPDE4BSMN1; SMN2 | |
| SCHEMBL7911734 | 0.84 | PDE4D (0.44) | PDE4DFBP1SNCAPDE4BMEN1 | |
| SCHEMBL3791461 | 0.84 | PDE4D (0.44) | PDE4DSNCAPDE4BSMN1; SMN2 | |
| SCHEMBL3467080 | 0.82 | PDE4B (0.42) | PDE4DFBP1SNCAPDE4BSMN1; SMN2 | |
| SCHEMBL3791661 | 0.82 | PDE4D (0.44) | PDE4DFBP1PDE4B | |
| SCHEMBL8057832 | 0.81 | PDE4D (0.49) | PDE4DFBP1SNCAPDE4BALDH1A1 | |
| SCHEMBL4326854 | 0.81 | PDE4D (0.48) | PDE4DFBP1SNCAPDE4BALDH1A1 | |
| SCHEMBL4326556 | 0.80 | PDE4B (0.41) | PDE4DSNCAPDE4BALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |