Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 16/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 16/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 16/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 16/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 16/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 16/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919203 | 0.82 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7922094 | 0.67 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7917420 | 0.67 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1726560 | 0.64 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27819262 | 0.63 | GAA (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7095231 | 0.63 | PTGDR2 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5235675 | 0.63 | PTGDR2 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21286134 | 0.61 | NR2E1 (0.68) | NR2E1EP300 | |
| Nitric Acid SCHEMBL1617375 | 0.61 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Nitric Acid SCHEMBL1617372 | 0.61 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052199-A1 | HETEROCYCLIC GAMMA SECRETASE MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-14 | — | — | WO | disclosed |