Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918528 | 1.00 | HCRTR2 (0.49) | HCRTR2NR1H2NR1H3OPRD1MEN1 | |
| SCHEMBL143674 | 0.89 | LMNA (0.47) | HCRTR2OPRD1MEN1KMT2AAPP | |
| SCHEMBL86666 | 0.89 | LMNA (0.47) | HCRTR2OPRD1MEN1KMT2AAPP | |
| SCHEMBL345625 | 0.89 | LMNA (0.47) | HCRTR2OPRD1MEN1KMT2AAPP | |
| SCHEMBL9850372 | 0.87 | STS (0.51) | MEN1KMT2AAPPHTR1AADRA2A | |
| SCHEMBL7734440 | 0.87 | MEN1 (0.46) | HCRTR2NR1H2NR1H3OPRD1MEN1 | |
| SCHEMBL28433249 | 0.87 | MEN1 (0.46) | HCRTR2NR1H2NR1H3OPRD1MEN1 | |
| SCHEMBL9850364 | 0.87 | STS (0.51) | MEN1KMT2AAPPHTR1AADRA2A | |
| SCHEMBL4809535 | 0.86 | LMNA (0.43) | HCRTR2MEN1KMT2AKDM1AAPP | |
| SCHEMBL29407129 | 0.85 | STS (0.51) | HCRTR2NR1H2NR1H3OPRD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |