Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700733 | 0.78 | ESR1 (0.38) | POLBESR1ESR2LMNAAR | |
| SCHEMBL7339642 | 0.77 | KCNN4 (0.41) | MEN1KMT2ASMN1; SMN2KIF11ESR1 | |
| SCHEMBL12936023 | 0.76 | MEN1 (0.48) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 | |
| Iodide SCHEMBL28547565 | 0.76 | KCNN4 (0.40) | MEN1KMT2ASMN1; SMN2KIF11ESR1 | |
| SCHEMBL10253668 | 0.74 | KMT2A (0.58) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL11028937 | 0.74 | MEN1 (0.41) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL13824285 | 0.74 | MEN1 (0.52) | MEN1KMT2APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL7034676 | 0.74 | MEN1 (0.46) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL7041297 | 0.74 | KMT2A (0.44) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL12054100 | 0.72 | ESR1 (0.46) | CYP19A1MEN1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140791-A4 | SELECTIVE CPLA 2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140791-A2 | SELECTIVE CPLA 2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-1999015129-A2 | SELECTIVE cPLA2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |