Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371285 | 1.00 | TACR1 (1.00) | TACR1 | |
| SCHEMBL7918701 | 1.00 | TACR1 (1.00) | TACR1 | |
| SCHEMBL7847280 | 0.93 | TACR1 (0.90) | TACR1 | |
| SCHEMBL8189473 | 0.92 | TACR1 (0.88) | TACR1 | |
| SCHEMBL8189477 | 0.92 | TACR1 (0.88) | TACR1 | |
| SCHEMBL9275371 | 0.92 | TACR1 (1.00) | TACR1 | |
| SCHEMBL9275375 | 0.92 | TACR1 (1.00) | TACR1 | |
| SCHEMBL8200979 | 0.92 | TACR1 (1.00) | TACR1 | |
| SCHEMBL8200980 | 0.92 | TACR1 (1.00) | TACR1 | |
| SCHEMBL8197471 | 0.89 | TACR1 (1.00) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239144-B1 | ADMINISTERING A TACHYKININ RECEPTOR ANTAGONIST, 2-(N-(2-((4-CYCDOHEXYL)PIPERAZIN-1-YL)ACETYL)AMINO)-3-(1H-INDO L-3-YL)-1-(N-(2-METHOXYBENZYL)ACETYLAMINO)PROPANE, | ELI LILLY AND COMPANY | 2001-05-29 | — | — | US | claimed |
| WO-1997044035-A1 | METHODS OF TREATING HYPERTENSION | ELI LILLY AND COMPANY (US) | 1997-11-27 | — | — | WO | claimed |
| EP-0747055-A2 | Use of tachykinin receptors antagonists for the treatment of cold and allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0747049-A1 | Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | claimed |
| EP-0655055-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1995-05-31 | — | — | EP | claimed |
| WO-1994004494-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1994-03-03 | — | — | WO | claimed |
| EP-1000930-A2 | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0655055-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004494-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |