Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376892 | 0.98 | HRH1 (0.59) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL7740622 | 0.95 | HRH1 (0.63) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL10663683 | 0.95 | HRH1 (0.63) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL11446555 | 0.95 | HRH1 (0.63) | HRH1LOXL2NAAAHRH3HRH4 | |
| Bromide SCHEMBL1428221 | 0.93 | HRH1 (0.54) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL708837 | 0.91 | HRH1 (0.56) | HRH1LOXL2NAAAHRH3HRH4 | |
| Hydrochloric Acid SCHEMBL8329183 | 0.88 | HRH1 (0.54) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL726645 | 0.85 | HRH1 (0.73) | HRH1LOXL2NAAAHRH3HRH4 | |
| Bromide SCHEMBL3395799 | 0.83 | LOXL2 (0.54) | HRH1LOXL2NAAAHRH3HRH4 | |
| SCHEMBL2841394 | 0.83 | HRH1 (0.77) | HRH1LOXL2NAAAHRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830388-A4 | ION EXCHANGE POLYMERS FOR ANION SEPARATIONS | UNIV CALIFORNIA (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0830388-A1 | ION EXCHANGE POLYMERS FOR ANION SEPARATIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-03-25 | — | — | EP | disclosed |
| US-5670550-A | ION EXCHANGING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) | 1997-09-23 | — | — | US | disclosed |
| WO-1996040803-A1 | ION EXCHANGE POLYMERS FOR ANION SEPARATIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0222474-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-03 | — | — | EP | disclosed |
| EP-0223344-B1 | GAMMA-CARBOLINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-22 | — | — | EP | disclosed |
| US-4942234-A | ANTIANXIETY AGENTS WITH FEW SIDE EFFECTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-07-17 | — | — | US | disclosed |
| US-4900835-A | Antipsychotic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-02-13 | — | — | US | disclosed |
| US-4883875-A | Antipsychotic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-11-28 | — | — | US | disclosed |
| US-4851533-A | 1,4-diazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| US-4833249-A | ANXIOLITIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-05-23 | — | — | US | disclosed |
| US-4719211-A | PSYCHOLOGIAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| US-4672117-A | Antipsychotic gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0223344-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |
| EP-0222474-A1 | Gamma-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-20 | — | — | EP | disclosed |
| US-4636563-A | Antipsychotic γ-carbolines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |