Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918102 | 0.90 | HTT (0.34) | BACE1HTTKCNH2BACE2TAAR1 | |
| SCHEMBL7911125 | 0.88 | TSHR (0.33) | BACE1TSHRLMNAMAPTKCNH2 | |
| SCHEMBL7913281 | 0.86 | TAAR1 (0.40) | BACE1HTTKCNH2BACE2TAAR1 | |
| SCHEMBL7923311 | 0.84 | TAAR1 (0.34) | BACE1HTTKCNH2BACE2TAAR1 | |
| SCHEMBL7924833 | 0.78 | TAAR1 (0.36) | TAAR1ADRA2A | |
| SCHEMBL7918694 | 0.78 | TAAR1 (0.35) | BACE1ALDH1A1MEN1KMT2ATAAR1 | |
| SCHEMBL7918099 | 0.77 | TAAR1 (0.31) | TAAR1ADRA2A | |
| SCHEMBL7923354 | 0.75 | TAAR1 (0.39) | BACE1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7916197 | 0.74 | TAAR1 (0.40) | BACE1TAAR1ADRA2A | |
| SCHEMBL7920016 | 0.74 | TAAR1 (0.40) | BACE1TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |