Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9459105 | 0.91 | CHRM1 (0.44) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9225381 | 0.83 | CHRM1 (0.52) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9226760 | 0.77 | CHRM1 (0.44) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9458720 | 0.75 | KMT2A (0.62) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9458880 | 0.75 | KMT2A (0.40) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9458909 | 0.75 | KMT2A (0.40) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9227574 | 0.74 | CHRM1 (0.43) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9459135 | 0.74 | CHRM1 (0.41) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9347006 | 0.70 | CHRM1 (0.54) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9430809 | 0.70 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871445-A4 | COMPOSITION FOR TREATING PAIN | LILLY CO ELI (US) | 2001-01-10 | — | — | EP | disclosed |
| EP-0871445-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997020561-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1997-06-12 | — | — | WO | disclosed |
| US-5574053-A | Method for treating anxiety | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5574029-A | Method for treating anxiety | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5574028-A | SEDATIVES | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |