Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458880 | 0.89 | KMT2A (0.40) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9459105 | 0.84 | CHRM1 (0.44) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9459148 | 0.82 | KMT2A (0.41) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9459183 | 0.81 | CHRM2 (0.37) | CHRM2 | |
| SCHEMBL9458890 | 0.78 | CHRM2 (0.44) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL7920314 | 0.75 | CHRM1 (0.54) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9227574 | 0.74 | CHRM1 (0.43) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9459135 | 0.74 | CHRM1 (0.41) | KMT2ACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL9459266 | 0.72 | CHRM2 (0.37) | CHRM2 | |
| SCHEMBL9458896 | 0.69 | CHRM1 (0.54) | KMT2ACHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |