Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920441 | 0.86 | MCHR1 (0.45) | MCHR1HTR1DHTR1BHTR2AMEN1 | |
| Hydrochloric Acid SCHEMBL7913385 | 0.86 | HTR1D (0.38) | CHRNB4CHRNA3HTR1DHTR1BHTR2A | |
| SCHEMBL7920434 | 0.82 | MCHR1 (0.45) | MCHR1CHRNB4CHRNA3CHRNB1CHRNB2 | |
| Oxalic Acid SCHEMBL7919986 | 0.78 | MAPT (0.33) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7448439 | 0.77 | HTR1D (0.54) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL6927404 | 0.74 | HTR1D (0.68) | MCHR1HTR1DHTR1BHTR2AMEN1 | |
| SCHEMBL6927402 | 0.74 | HTR1D (0.68) | MCHR1HTR1DHTR1BHTR2AMEN1 | |
| SCHEMBL6928603 | 0.74 | HTR1D (0.68) | MCHR1HTR1DHTR1BHTR2AMEN1 | |
| SCHEMBL8798964 | 0.72 | HTR1D (0.60) | MCHR1HTR1DHTR1BHTR2AMEN1 | |
| SCHEMBL6927766 | 0.70 | HTR1D (0.69) | MCHR1HTR1DHTR1BHTR2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |