SCHEMBL7920929

SCHEMBL7920929

COC(=O)c1ccccc1NC(Cc1ccc(O)cc1)C(=O)OC

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.51
MDM4 O15151 1/20 0.51
MDM2 Q00987 1/20 0.51
ELANE P08246 1/20 0.51
KMT2A Q03164 2/20 0.50
KDM4E B2RXH2 5/20 0.49
ALDH1A1 P00352 4/20 0.49
HPGD P15428 1/20 0.49
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
PPARG P37231 3/20 0.47
KDR P35968 1/20 0.47
PPARD Q03181 1/20 0.47
PPARA Q07869 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CNR1 P21554 1/20 0.47
CNR2 P34972 1/20 0.47
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.47
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1749468 0.86 PPARG (0.61) PPARGPPARA
SCHEMBL1719719 0.86 PPARG (0.61) PPARGPPARA
SCHEMBL4156967 0.86 PPARG (0.61) PPARGPPARA
SCHEMBL1719298 0.85 PPARG (0.48) TSHRMDM4MDM2ELANEESR1
SCHEMBL1719565 0.83 PPARG (0.53) PPARGPPARA
SCHEMBL1720449 0.83 PPARG (0.61) PPARGPPARAATM
SCHEMBL7920805 0.83 PPARG (0.55) PPARGPPARA
SCHEMBL7921154 0.83 PPARG (0.62) PPARGPPARA
SCHEMBL7898915 0.83 ELANE (0.48) TSHRMDM4MDM2ELANEKMT2A
SCHEMBL7415561 0.81 PPARG (0.58) KMT2AKDM4EALDH1A1PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294580-B1 FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE GLAXO WELLCOME INC. 2001-09-25 US disclosed
EP-0888317-B1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LTD (GB) 2001-09-12 EP disclosed
EP-0888317-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1999-01-07 EP disclosed
WO-1997031907-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1997-09-04 WO disclosed