Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283777 | 0.88 | CHRM1 (0.62) | CHRM1CACNA1HCACNA1GCACNA1ILMNA | |
| SCHEMBL12376469 | 0.85 | CHRM1 (0.53) | CHRM1P2RX3ALDH1A1KMT2ALMNA | |
| SCHEMBL2288496 | 0.83 | CHRM1 (0.47) | CHRM1P2RX3DRD4SIGMAR1KDM4E | |
| SCHEMBL7937581 | 0.80 | CHRM1 (0.58) | CHRM1P2RX3KDM4EALDH1A1KMT2A | |
| SCHEMBL1931223 | 0.80 | CHRM1 (0.58) | CHRM1P2RX3KDM4EALDH1A1KMT2A | |
| SCHEMBL14922852 | 0.79 | CHRM1 (0.50) | CHRM1P2RX3KDM4EALDH1A1KMT2A | |
| SCHEMBL1550419 | 0.79 | CHRM1 (0.50) | CHRM1P2RX3DRD4KDM4EALDH1A1 | |
| SCHEMBL1931415 | 0.78 | CHRM1 (0.48) | CHRM1P2RX3KDM4EALDH1A1KMT2A | |
| SCHEMBL1931435 | 0.78 | CHRM1 (0.48) | CHRM1P2RX3KDM4EALDH1A1KMT2A | |
| SCHEMBL1931477 | 0.77 | CHRM1 (0.48) | CHRM1P2RX3KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436016-B2 | Fused heterocyclic M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. | 2013-05-07 | — | — | US | disclosed |
| US-20110201607-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck, Sharp & Dohme, Corp. | 2011-08-18 | — | — | US | disclosed |
| US-20110201607-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck, Sharp & Dohme, Corp. | 2011-08-18 | — | — | US | disclosed |
| WO-2010047990-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201607-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, OPRM1 | CHRM1 1/4885P2RX3 124/4885CACNA1H 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.