Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13227978 | 1.00 | SYK (0.35) | SYKCNKSR1CHRM4MAPK8MAPK9 | |
| SCHEMBL10043016 | 0.94 | PDE4B (0.37) | CNKSR1CHRM4PDE4BCA12CA1 | |
| SCHEMBL3338943 | 0.87 | CNKSR1 (0.34) | SYKCNKSR1MAPK8MAPK9ADORA1 | |
| SCHEMBL394569 | 0.86 | CHRM4 (0.36) | CHRM4MAPK8MAPK9ADORA1ADORA3 | |
| SCHEMBL394570 | 0.86 | CHRM4 (0.36) | CHRM4MAPK8MAPK9ADORA1ADORA3 | |
| SCHEMBL8210284 | 0.85 | ALOX15 (0.40) | CNKSR1 | |
| SCHEMBL13406842 | 0.84 | CHUK (0.37) | CNKSR1MAPK8MAPK9CA12CA1 | |
| SCHEMBL8210412 | 0.84 | CHUK (0.37) | CNKSR1MAPK8MAPK9CA12CA1 | |
| SCHEMBL8202236 | 0.83 | MAPK8 (0.38) | CNKSR1MAPK8MAPK9 | |
| SCHEMBL12680250 | 0.80 | PIK3CA (0.39) | CNKSR1P2RY12PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101622-B2 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101622-B2 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| WO-2010039740-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα AND MTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | PIK3CD, PIK3CA, MTOR | SYK 322/4885CNKSR1 645/4885CHRM4 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.