Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.46 |
| ▸ | PPARA | Q07869 | 14/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5278893 | 0.86 | PPARG (0.58) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL9436449 | 0.85 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL20125582 | 0.85 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL37497 | 0.85 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL674635 | 0.84 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL2787459 | 0.82 | PPARG (0.44) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL7927937 | 0.81 | PPARG (0.46) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL243882 | 0.80 | PPARG (0.44) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL13960286 | 0.80 | KDM4E (0.55) | PPARGPPARAFFAR1PPARDKDM4E | |
| SCHEMBL9097431 | 0.79 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143953-A3 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1143953-A2 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000030628-A2 | METHOD OF INHIBITING ANGIOGENESIS | GENENTECH, INC. (US) | 2000-06-02 | — | — | WO | disclosed |