Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.46 |
| ▸ | PPARA | Q07869 | 15/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1220163 | 0.84 | PPARG (0.45) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL9436449 | 0.83 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL20125582 | 0.83 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9097431 | 0.83 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL37497 | 0.83 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| Darglitazone SCHEMBL674635 | 0.83 | PPARG (0.48) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL7921252 | 0.81 | PPARG (0.46) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL13960286 | 0.80 | KDM4E (0.55) | PPARGPPARAFFAR1KDM4EPPARD | |
| SCHEMBL1082732 | 0.80 | PPARG (0.46) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL7483358 | 0.79 | FFAR1 (0.46) | PPARGPPARAFFAR1KDM4EPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169099-B1 | INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH SQUALENE SYNTHESIS INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-02 | — | — | US | disclosed |