Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.47 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.36 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.36 |
| ▸ | TLR4 | O00206 | 3/20 | 0.34 |
| ▸ | CD14 | P08571 | 3/20 | 0.34 |
| ▸ | LY96 | Q9Y6Y9 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568857 | 0.81 | RXRA (0.43) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL7921794 | 0.80 | RXRA (0.50) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL4862938 | 0.79 | RXRA (0.46) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL14594240 | 0.79 | RXRA (0.47) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL4860379 | 0.78 | RXRA (0.47) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6915961 | 0.77 | RXRA (0.39) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL13130673 | 0.76 | RXRA (0.40) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6473245 | 0.76 | RXRA (0.46) | RXRAPPARGRARGRXRBRXRG | |
| SCHEMBL6567748 | 0.75 | RARG (0.36) | RXRAPPARGRARGNR5A2NR5A1 | |
| SCHEMBL6608332 | 0.74 | RXRA (0.45) | RXRAPPARGRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161410-A1 | RETINOID ANTAGONISTS AND USE THEREOF | Basilea Pharmaceutica AG (CH) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053562-A1 | RETINOID ANTAGONISTS AND USE THEREOF | BASILEA PHARMACEUTICA AG (CH) | 2000-09-14 | — | — | WO | disclosed |