Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 12/20 | 0.73 |
| ▸ | CTSL | P07711 | 6/20 | 0.69 |
| ▸ | CTSB | P07858 | 5/20 | 0.69 |
| ▸ | CTSS | P25774 | 3/20 | 0.69 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18848786 | 0.91 | CTSK (0.75) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL14514052 | 0.91 | CTSK (0.75) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8971948 | 0.89 | CTSK (0.72) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL1841693 | 0.88 | CTSK (0.70) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8823980 | 0.88 | CTSK (0.73) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8823928 | 0.88 | CTSK (0.73) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL25406813 | 0.87 | CTSK (0.77) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL8823918 | 0.87 | CTSK (0.77) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL20770085 | 0.87 | CTSK (0.77) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL4872585 | 0.87 | CTSK (0.77) | CTSKCTSLCTSBCTSSCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331542-B1 | TREATING DISEASES CHARACTERIZED BY BONE LOSS OR EXCESSIVE CARTILAGE OR MATRIX DEGRADATION | SMITHKLINE BEECHAM CORPORATION | 2001-12-18 | — | — | US | disclosed |
| US-6232342-B1 | CATHEPSIN K INHIBITOR FOR TREATING OSTEOPOROSIS, GINGIVITIS, PERIODONTITIS, ARTHRITIS, OSTEOARTHRITIS RHEUMATOID ARTHRITIS, PAGET'S DISEASE, HYPERCALCEMIA OF MALIGNANCY AND METABOLIC BONE DISEASES | SMITHKLINE BEECHAM CORPORATION | 2001-05-15 | — | — | US | disclosed |