Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.69 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678814 | 0.91 | MCHR1 (0.73) | MCHR1KDRHTR2CNR1H4HTR1D | |
| SCHEMBL6928640 | 0.86 | MCHR1 (0.92) | MCHR1HTR2CHTR1DHTR1BHTR2A | |
| SCHEMBL6927547 | 0.83 | MCHR1 (0.75) | MCHR1KDRHTR2CHTR1DHTR1B | |
| SCHEMBL7646291 | 0.82 | MCHR1 (0.74) | MCHR1KDRHTR2C | |
| SCHEMBL6920493 | 0.81 | MCHR1 (0.76) | MCHR1KDRHTR2CHTR1DHTR1B | |
| SCHEMBL6926020 | 0.81 | MCHR1 (0.80) | MCHR1HTR2C | |
| SCHEMBL6927530 | 0.80 | MCHR1 (0.76) | MCHR1KDRHTR2CHTR1DHTR1B | |
| SCHEMBL6927561 | 0.80 | MCHR1 (0.76) | MCHR1KDRHTR2CHTR1DHTR1B | |
| SCHEMBL7670306 | 0.79 | MCHR1 (0.77) | MCHR1HTR2C | |
| SCHEMBL6927709 | 0.78 | MCHR1 (0.77) | MCHR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |