Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 11/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374258 | 0.93 | IL2 (0.40) | HDAC6IL2TRPV1STIM1ORAI1 | |
| Hydrochloric Acid SCHEMBL1782166 | 0.92 | IL2 (0.39) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL7922608 | 0.92 | IL2 (0.43) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL1781058 | 0.92 | HDAC6 (0.40) | HDAC6IL2TRPV1STIM1ORAI1 | |
| Hydrochloric Acid SCHEMBL614560 | 0.91 | IL2 (0.43) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL1780826 | 0.90 | IL2 (0.38) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL1782159 | 0.87 | IL2 (0.42) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL7920820 | 0.85 | STIM1 (0.44) | IL2TRPV1STIM1ORAI1ORAI2 | |
| SCHEMBL614875 | 0.85 | IL2 (0.43) | HDAC6IL2TRPV1STIM1ORAI1 | |
| SCHEMBL7914099 | 0.85 | IL2 (0.41) | IL2TRPV1STIM1ORAI1ORAI2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039236-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-08 | — | — | WO | disclosed |