Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975282 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL9190477 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL2441406 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL10141498 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL3472519 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL9196316 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL24919991 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL9190483 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL1896639 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM | |
| SCHEMBL8435960 | 1.00 | TP53 (0.57) | TP53HTTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-05-24 | — | — | US | disclosed |
| EP-0814073-B1 | Epimerization of 2- or 4-substituted cyclohexanecarboxylic acids | KATAYAMA SEISAKUSHO (JP) | 2001-09-12 | — | — | EP | disclosed |
| US-5831118-A | HEATING WITH POTASSIUM HYDROXIDE; ONE STEP | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1998-11-03 | — | — | US | disclosed |
| EP-0814073-A1 | Epimerization of 2- or 4-substituted cyclohexanecarboxylic acids | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1997-12-29 | — | — | EP | disclosed |
| EP-0394906-B1 | Liquid crystalline composition | MERCK PATENT GMBH (DE) | 1995-12-20 | — | — | EP | disclosed |
| EP-0315958-B1 | OPTICALLY ACTIVE MESOMORPHIC COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING SAME | CANON KABUSHIKI KAISHA (JP) | 1993-03-10 | — | — | EP | disclosed |
| US-5182047-A | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-26 | — | — | US | disclosed |
| EP-0368975-B1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1992-12-16 | — | — | EP | disclosed |
| EP-0394906-A2 | Liquid crystalline composition | MERCK PATENT GmbH (DE) | 1990-10-31 | — | — | EP | disclosed |
| EP-0368975-A1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1990-05-23 | — | — | EP | disclosed |
| US-4917821-A | Optically active mesomorphic compound and liquid crystal composition containing same | CANON KABUSHIKI KAISHA (JP) | 1990-04-17 | — | — | US | disclosed |
| WO-1989012039-A1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-12-14 | — | — | WO | disclosed |
| EP-0315958-A2 | Optically active mesomorphic compound and liquid crystal composition containing same | CANON KABUSHIKI KAISHA (JP) | 1989-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141941-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | NR1H4, FXR1, SLC10A1 | TP53 4394/4885HTT 3363/4885MEN1 4363/4885 |
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | TP53 4394/4885HTT 3363/4885MEN1 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.