Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28998866 | 0.93 | UGT2B7 (0.35) | UGT2B7LMNAGAACYP1A2FFAR3 | |
| Hydrogen Peroxide SCHEMBL27561732 | 0.93 | GAA (0.38) | UGT2B7GAA | |
| Acetic Acid SCHEMBL29152895 | 0.91 | UGT2B7 (0.34) | UGT2B7LMNAGAACYP1A2FFAR3 | |
| Methyl Alcohol SCHEMBL8166102 | 0.88 | GAA (0.38) | GAA | |
| SCHEMBL11280434 | 0.88 | — | — | |
| SCHEMBL201821 | 0.88 | — | — | |
| Carbamic Acid SCHEMBL28182171 | 0.88 | EPHX1 (0.35) | UGT2B7SMN1; SMN2GAACYP1A2 | |
| Acrylic Acid SCHEMBL17974546 | 0.86 | LMNA (0.37) | UGT2B7LMNA | |
| Methacrylic Acid SCHEMBL28063307 | 0.86 | SMN1; SMN2 (0.33) | UGT2B7SMN1; SMN2GAAPOLB | |
| Acrylic Acid SCHEMBL1615618 | 0.86 | LMNA (0.37) | UGT2B7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884309-A | Increase-volume composition, the product formed by it and manufacturing method | 沙特基础工业全球技术有限公司 | 2018-11-23 | — | — | CN | claimed |
| CN-109415534-A | The polycarbonate compositions of optical property with enhancing, the product formed by it and manufacturing method | 沙特基础工业全球技术有限公司 | 2019-03-01 | — | — | CN | disclosed |
| EP-0835860-B1 | Process for the preparation of esters or alcoholates by water separation | BAYER AG (DE) | 2001-06-13 | — | — | EP | disclosed |
| EP-0835860-A1 | Separation of water from reactive mixtures | BAYER AG (DE) | 1998-04-15 | — | — | EP | disclosed |