Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGCG | Q16739 | 7/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12406377 | 0.90 | UGCG (0.70) | UGCGOPRM1PTGS1HTR1ASMN1; SMN2 | |
| SCHEMBL14870559 | 0.90 | UGCG (0.70) | UGCGOPRM1PTGS1HTR1ASMN1; SMN2 | |
| SCHEMBL14859180 | 0.90 | UGCG (0.70) | UGCGOPRM1PTGS1HTR1ASMN1; SMN2 | |
| SCHEMBL17937281 | 0.87 | UGCG (0.66) | UGCGOPRM1PTGS1HTR1ASMN1; SMN2 | |
| SCHEMBL13492954 | 0.86 | UGCG (0.49) | UGCGOPRM1PTGS1HTR1AKDM4E | |
| SCHEMBL12406552 | 0.85 | UGCG (0.66) | UGCGOPRM1PTGS1HTR1AOPRK1 | |
| SCHEMBL7993471 | 0.84 | UGCG (0.58) | UGCGOPRM1PTGS1HTR1AKDM4E | |
| SCHEMBL12406558 | 0.83 | UGCG (0.64) | UGCGOPRM1PTGS1HTR1A | |
| SCHEMBL12406390 | 0.82 | UGCG (0.68) | UGCGOPRM1PTGS1HTR1AOPRK1 | |
| SCHEMBL2167845 | 0.82 | UGCG (0.65) | UGCGOPRM1PTGS1HTR1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |