Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394002 | 0.89 | METAP2 (0.57) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL2781605 | 0.85 | METAP2 (0.53) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL4393939 | 0.85 | METAP2 (0.53) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6535609 | 0.84 | METAP2 (0.52) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL8236564 | 0.84 | METAP2 (0.52) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL4792326 | 0.82 | PLAU (0.55) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL2484187 | 0.82 | METAP2 (0.55) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL3212638 | 0.81 | METAP2 (0.57) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL10437729 | 0.81 | METAP2 (0.49) | METAP2PLAUNCF1ALOX12ALDH1A1 | |
| SCHEMBL9220073 | 0.79 | CCR1 (0.65) | METAP2PLAUNCF1ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174898-B1 | TREATING FILARIAE IN LYMPHATIC SYSTEM BY ADMINISTERING N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF N-SUBSTITUENT AND SALTS | NOVO NORDISK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| EP-0858339-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997017073-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1997-05-15 | — | — | WO | disclosed |
| EP-0342635-B1 | Azacyclic carboxylic acid derivatives, their preparation and use | NOVO NORDISK AS (DK) | 1994-08-17 | — | — | EP | disclosed |
| US-5231106-A | Nervous sytem disorders; blocking og gamma aminobutyric acid | NOVO NORDISK A/S (DK) | 1993-07-27 | — | — | US | disclosed |
| US-5229404-A | Inhibitors of gamma-aminobutyric acid re-uptake, antiepileptic agents | NOVO NORDISK A/S (DK) | 1993-07-20 | — | — | US | disclosed |
| US-5214054-A | Gamma-aminobutyric acid re-uptake inhibitors, antiepileptic, analgesics, anxiolytics | NOVO NORDISK A/S (DK) | 1993-05-25 | — | — | US | disclosed |
| US-5039685-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-08-13 | — | — | US | disclosed |
| EP-0342635-A1 | Azacyclic carboxylic acid derivatives, their preparation and use | NOVO NORDISK A/S (DK) | 1989-11-23 | — | — | EP | disclosed |