Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.46 |
| ▸ | EDNRB | P24530 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620426 | 0.87 | MAOB (0.52) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8294001 | 0.84 | EDNRA (0.44) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8207341 | 0.83 | CFTR (0.39) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8624507 | 0.74 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL7665196 | 0.73 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL6951608 | 0.73 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8622977 | 0.73 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL6955353 | 0.73 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL7748131 | 0.72 | NPC1 (0.41) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL7659711 | 0.72 | NPC1 (0.41) | EDNRAEDNRBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274737-B1 | CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2001-08-14 | — | — | US | disclosed |
| US-5817693-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 1998-10-06 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| WO-1993008799-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-13 | — | — | WO | disclosed |