Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 18/20 | 0.48 |
| ▸ | TSHR | P16473 | 9/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934295 | 0.78 | ALDH1A1 (0.61) | ALDH1A1TSHRLMNAUSP2HTT | |
| SCHEMBL7924284 | 0.74 | ALDH1A1 (0.57) | ALDH1A1TSHRLMNAUSP2HTT | |
| SCHEMBL12225969 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRLMNAUSP2HTT | |
| SCHEMBL7924136 | 0.71 | ALDH1A1 (0.58) | ALDH1A1TSHRPKMLMNAUSP2 | |
| SCHEMBL17708393 | 0.69 | ALDH1A1 (0.65) | ALDH1A1TSHRPKMLMNAUSP2 | |
| SCHEMBL2538104 | 0.68 | MEN1 (0.58) | ALDH1A1TSHRPKMLMNAUSP2 | |
| SCHEMBL15337542 | 0.68 | ALDH1A1 (0.66) | ALDH1A1TSHRPKMLMNAUSP2 | |
| SCHEMBL1493311 | 0.67 | ALDH1A1 (0.76) | ALDH1A1TSHRPKMLMNAUSP2 | |
| SCHEMBL1493501 | 0.64 | ALDH1A1 (0.63) | ALDH1A1TSHRLMNAUSP2HTT | |
| SCHEMBL8185020 | 0.63 | GAA (0.72) | ALDH1A1TSHRPKMLMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010034003-A2 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257177-A1 | BENZYLTHIOTETRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | SARAF, CACNA1I, ORAI1 | ALDH1A1 4357/4885TSHR 4275/4885PKM 3410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.