Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.59 |
| ▸ | MTOR | P42345 | 20/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2288681 | 0.90 | PIK3CA (0.74) | PIK3CAMTORALKPIK3CDPIK3C2A | |
| SCHEMBL7921952 | 0.86 | MTOR (0.63) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL7915933 | 0.85 | PIK3CA (0.81) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL7913788 | 0.84 | MTOR (0.81) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL7925383 | 0.84 | PIK3CA (0.82) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL7923878 | 0.83 | MTOR (0.81) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL7924993 | 0.83 | PIK3CA (0.59) | PIK3CAMTORALKPIK3CDPIK3C2A | |
| SCHEMBL17031465 | 0.80 | PIK3CA (0.62) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL2281822 | 0.76 | MTOR (0.79) | PIK3CAMTORALKLCKLYN | |
| SCHEMBL22616561 | 0.74 | MTOR (0.73) | PIK3CAMTORALKPIK3CDPIK3C2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038165-A1 | IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2010-04-08 | — | — | WO | disclosed |