Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.59 |
| ▸ | MTOR | P42345 | 19/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.58 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.58 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | NEK2 | P51955 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279824 | 0.89 | PIK3CA (0.77) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL7922488 | 0.86 | MTOR (0.78) | PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL10228687 | 0.84 | MTOR (0.79) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL7923875 | 0.84 | PIK3CA (0.79) | PIK3CAMTOR | |
| SCHEMBL7925379 | 0.84 | MTOR (0.79) | PIK3CAMTOR | |
| SCHEMBL7920281 | 0.84 | MTOR (0.79) | PIK3CAMTOR | |
| SCHEMBL7924523 | 0.84 | MTOR (0.81) | PIK3CAMTOR | |
| SCHEMBL7924992 | 0.83 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL16211785 | 0.77 | MTOR (0.82) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL31439358 | 0.76 | PIK3CA (0.82) | PIK3CAMTORPIK3CDPIK3C2APIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038165-A1 | IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2010-04-08 | — | — | WO | disclosed |