SCHEMBL7926436

SCHEMBL7926436

Oc1c(I)ccc(Cl)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.46
MAPK1 P28482 3/20 0.46
HSD17B10 Q99714 7/20 0.43
TSHR P16473 6/20 0.43
HPGD P15428 5/20 0.43
CASP1 P29466 1/20 0.43
NOTUM Q6P988 1/20 0.41
DPP4 P27487 1/20 0.34
ALDH1A1 P00352 4/20 0.33
TDP1 Q9NUW8 2/20 0.33
MEN1 O00255 2/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 1/20 0.33
USP2 O75604 1/20 0.33
TP53 P04637 1/20 0.33
APP P05067 1/20 0.33
CYP1A2 P05177 1/20 0.33
HSP90AA1 P07900 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16837415 0.79 MAPK1 (0.46) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL14207902 0.79 NOTUM (0.46) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL581831 0.77 CYP3A4 (0.55) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL31506484 0.77 CYP3A4 (0.55) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL28768733 0.77 NOTUM (0.45) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL22884870 0.75 CYP3A4 (0.35) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL6505405 0.75 NOTUM (0.52) CYP3A4MAPK1TSHRNOTUMTDP1
SCHEMBL12302293 0.73 TTR (0.44) CYP3A4MAPK1HSD17B10HPGDALDH1A1
SCHEMBL29499539 0.72 CYP3A4 (0.65) CYP3A4MAPK1HSD17B10TSHRHPGD
SCHEMBL69375 0.72 CYP3A4 (0.65) CYP3A4MAPK1HSD17B10TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102906129-B Process for selectively polymerizing ethylene and catalyst therefor DOW GLOBAL TECHNOLOGIES LLC 2015-02-25 CN disclosed
CN-102471792-B Method for producing ultrapure galactooligosaccharides INALCO SPA 2014-12-10 CN disclosed
EP-1155073-A1 PLASTIC MOULDING MATERIALS WHICH CAN BE DETECTED BY X-RAY CONTRAST Bayer Aktiengesellschaft (DE) 2001-11-21 EP disclosed
WO-2000036002-A1 PLASTIC MOULDING MATERIALS WHICH CAN BE DETECTED BY X-RAY CONTRAST BAYER AKTIENGESELLSCHAFT (DE) 2000-06-22 WO disclosed
EP-0975709-A1 ELECTROCHROMIC POLYMERIC SOLID FILMS, MANUFACTURING ELECTROCHROMIC DEVICES USING SUCH SOLID FILMS, AND PROCESSES FOR MAKING SUCH SOLID FILMS AND DEVICES DONNELLY CORPORATION (US) 2000-02-02 EP disclosed
WO-1998042796-A1 ELECTROCHROMIC POLYMERIC SOLID FILMS, MANUFACTURING ELECTROCHROMIC DEVICES USING SUCH SOLID FILMS, AND PROCESSES FOR MAKING SUCH SOLID FILMS AND DEVICES DONNELLY CORPORATION (US) 1998-10-01 WO disclosed