Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | MDH1 | P40925 | 2/20 | 0.39 |
| ▸ | MDH2 | P40926 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 6/20 | 0.37 |
| ▸ | RARG | P13631 | 6/20 | 0.37 |
| ▸ | RARA | P10276 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.35 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926544 | 0.92 | HIF1A (0.39) | HIF1AEPAS1MDH1MDH2EP300 | |
| SCHEMBL7927690 | 0.92 | RARB (0.43) | HIF1AEPAS1RARBRARGRARA | |
| SCHEMBL7930122 | 0.91 | HIF1A (0.43) | HIF1AEPAS1MDH1MDH2EP300 | |
| SCHEMBL7927824 | 0.91 | HIF1A (0.43) | HIF1AEPAS1MDH1MDH2EP300 | |
| SCHEMBL7926559 | 0.83 | RARB (0.44) | HIF1AEPAS1RARBRARGRARA | |
| SCHEMBL7929851 | 0.83 | RARB (0.45) | HIF1AEPAS1RARBRARGRARA | |
| SCHEMBL8457308 | 0.81 | PTPN11 (0.39) | HIF1AEPAS1RARBRARGRARA | |
| SCHEMBL7920646 | 0.81 | RARB (0.48) | HIF1AEPAS1RARBRARGRARA | |
| SCHEMBL7926532 | 0.79 | HDAC3 (0.39) | HIF1ARARBRARGRARALMNA | |
| SCHEMBL7927269 | 0.78 | HDAC3 (0.40) | RARBRARGRARALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225328-B1 | FOR THERAPY OF DISORDERS OR AILMENTS RELATED TO AN OVERREGULATION OF RETINOIC ACID RECEPTORS AND/OR TO HYPERVIAMINOSIS A | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2001-05-01 | — | — | US | disclosed |