Bromide

Bromide

SCHEMBL7927416

Br.BrCCCCCCc1ccccn1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.44
HRH1 P35367 2/20 0.65
NAAA Q02083 1/20 0.54
CYP1A2 P05177 4/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
CYP2C19 P33261 2/20 0.51
HRH3 Q9Y5N1 2/20 0.47
HRH4 Q9H3N8 1/20 0.46
ALDH1A1 P00352 2/20 0.46
LMNA P02545 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46
ALOX15 P16050 1/20 0.46
MAPT P10636 1/20 0.46
LIN28A Q9H9Z2 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL10378020 0.98 HRH1 (0.61) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL28347622 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL29145044 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL28136022 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL9670413 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL7007425 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL29263622 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL29031284 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL28669182 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19
SCHEMBL28260636 0.98 HRH1 (0.67) HRH1NAAACYP1A2SMN1; SMN2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0830388-A4 ION EXCHANGE POLYMERS FOR ANION SEPARATIONS UNIV CALIFORNIA (US) 2001-03-21 EP disclosed
EP-0830388-A1 ION EXCHANGE POLYMERS FOR ANION SEPARATIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-03-25 EP disclosed
US-5670550-A ION EXCHANGING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 1997-09-23 US disclosed
WO-1996040803-A1 ION EXCHANGE POLYMERS FOR ANION SEPARATIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-12-19 WO disclosed