Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 2/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521045 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL11505765 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL7117062 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL1818771 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL16520164 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL28385453 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL1520430 | 0.75 | ALDH1A1 (0.58) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL77922 | 0.75 | ALDH1A1 (0.62) | ALDH1A1HTTTSHRHPGDMAOB | |
| SCHEMBL1811434 | 0.75 | ALDH1A1 (0.62) | ALDH1A1HTTTSHRHPGDKAT2B | |
| SCHEMBL30408060 | 0.75 | ALDH1A1 (0.62) | ALDH1A1HTTTSHRHPGDKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232463-B1 | CROSSLINKING OLIGONUCLEOTIDES CONTAINING PURINE ANALOGS HAVING REACTIVE SITES ON THE NUCLEOBASE AND ON A SUGAR MOIETY; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-05-15 | — | — | US | disclosed |
| US-5811534-A | PURINE-BASED COMPOUNDS FOR INCLUSION INTO OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| US-5681941-A | GENETIC ENGINEERING; CROSSLINKING OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |