SCHEMBL7928138

SCHEMBL7928138

CO[C@H]1COC[C@]2(c3cc(N)ccc3F)N=C(NC(=O)OC(C)(C)C)SCC12

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 17/20 0.38
BACE2 Q9Y5Z0 16/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7922777 1.00 BACE1 (0.38) BACE1BACE2
SCHEMBL9913134 1.00 BACE1 (0.38) BACE1BACE2
SCHEMBL9913131 0.91 BACE1 (0.40) BACE1BACE2
SCHEMBL7918892 0.91 BACE1 (0.40) BACE1BACE2
SCHEMBL7927021 0.91 BACE1 (0.40) BACE1BACE2
SCHEMBL2340636 0.91 BACE1 (0.40) BACE1BACE2
SCHEMBL7924432 0.91 BACE1 (0.40) BACE1BACE2
SCHEMBL3302986 0.89 BACE1 (0.41) BACE1BACE2
SCHEMBL3302980 0.89 BACE1 (0.41) BACE1BACE2
SCHEMBL2619895 0.89 BACE1 (0.36) BACE1BACE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010038686-A1 NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) 2010-04-08 WO disclosed