Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 11/20 | 0.49 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101255 | 0.87 | IL2 (0.44) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL1780921 | 0.87 | IL2 (0.44) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL12603939 | 0.86 | IL2 (0.45) | IL2STIM1ORAI1ORAI2MEN1 | |
| Hydrochloric Acid SCHEMBL614866 | 0.86 | IL2 (0.44) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL7928293 | 0.86 | IL2 (0.45) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL7922608 | 0.85 | IL2 (0.43) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL1782123 | 0.85 | IL2 (0.43) | IL2STIM1ORAI1ORAI2MEN1 | |
| Hydrochloric Acid SCHEMBL614560 | 0.85 | IL2 (0.43) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL1782027 | 0.85 | ALDH1A1 (0.52) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL3825246 | 0.84 | IL2 (0.44) | IL2STIM1ORAI1ORAI2HTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039236-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-08 | — | — | WO | disclosed |