Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | HTR2B | P41595 | 3/20 | 0.57 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608630 | 0.82 | CYP2C9 (0.69) | CYP2C9CYP2C19MAPK14HTR2BSPR | |
| SCHEMBL7240895 | 0.78 | CYP2C9 (0.59) | CYP2C9CYP2C19MAPK14HTR2BSPR | |
| SCHEMBL7231924 | 0.76 | CYP2C9 (0.69) | CYP2C9CYP2C19MAPK14HTR2BSPR | |
| SCHEMBL7232623 | 0.75 | CYP2C9 (0.73) | CYP2C9CYP2C19MAPK14HTR2BSPR | |
| SCHEMBL3463671 | 0.74 | CYP2C9 (1.00) | CYP2C9CYP2C19MAPK14HTR2BSPR | |
| SCHEMBL10720113 | 0.70 | CYP2C9 (0.81) | CYP2C9CYP2C19MAPK14HTR2BMEN1 | |
| SCHEMBL27700477 | 0.67 | MEN1 (0.60) | CYP2C9CYP2C19MAPK14HTR2BMEN1 | |
| SCHEMBL7234134 | 0.67 | CYP2C9 (1.00) | CYP2C9CYP2C19MAPK14HTR2BMEN1 | |
| SCHEMBL3923737 | 0.67 | KDM4E (0.64) | CYP2C9CYP2C19MAPK14HTR2BMEN1 | |
| SCHEMBL5820252 | 0.67 | CYP2C9 (0.77) | CYP2C9CYP2C19MAPK14HTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107758-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012074-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2000-03-09 | — | — | WO | disclosed |