Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.56 |
| ▸ | CASR | P41180 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31580808 | 0.86 | KDM4E (0.71) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1462332 | 0.86 | KDM4E (0.71) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7897521 | 0.84 | CXCR2 (0.61) | CXCR2KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL5594974 | 0.84 | KMT2A (0.61) | CXCR2KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21753682 | 0.83 | CYP3A4 (0.65) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6853270 | 0.81 | CXCR2 (0.77) | CXCR2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL21753713 | 0.81 | KDM4E (0.57) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL30810149 | 0.80 | ALDH1A1 (0.63) | CXCR2KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL4348999 | 0.80 | KMT2A (0.70) | CXCR2KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL4354878 | 0.80 | MEN1 (0.73) | CXCR2KDM4EMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262113-B1 | HYDROXY- OR MERCAPTO-PHENYLUREAS | SMITHKLINE BEECHAM CORPORATION | 2001-07-17 | — | — | US | disclosed |
| US-6211373-B1 | Phenyl urea antagonists of the IL-8 receptor | SMITHKLINE BEECHAM CORPORATION | 2001-04-03 | — | — | US | disclosed |
| US-5780483-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |