SCHEMBL7928924

SCHEMBL7928924

O=C(O)c1ccc(C#CC=Cc2ccccc2-c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RARB P10826 8/20 0.44
RARG P13631 7/20 0.44
RARA P10276 6/20 0.44
RXRA P19793 2/20 0.44
BACE1 P56817 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
FFAR1 O14842 1/20 0.36
GRIN2D O15399 2/20 0.36
GRIN3B O60391 2/20 0.36
GRIN1 Q05586 2/20 0.36
GRIN2A Q12879 2/20 0.36
GRIN2B Q13224 2/20 0.36
GRIN2C Q14957 2/20 0.36
GRIN3A Q8TCU5 2/20 0.36
PTPN11 Q06124 1/20 0.36
EGFR P00533 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6479998 1.00 RARB (0.44) RARBRARGRARARXRABACE1
SCHEMBL6473734 1.00 RARB (0.44) RARBRARGRARARXRABACE1
SCHEMBL7931791 0.92 BACE1 (0.44) RARBRARGRARARXRABACE1
SCHEMBL1683992 0.91 RARB (0.53) RARBRARGRARARXRARXRB
SCHEMBL7930817 0.91 RARB (0.41) RARBRARGRARARXRABACE1
SCHEMBL7922764 0.91 ALOX15 (0.41) RARBRARGRARARXRARXRB
SCHEMBL7929309 0.91 BCL2L1 (0.45) RARBRARGRARARXRARXRB
SCHEMBL7922763 0.91 ALOX15 (0.41) RARBRARGRARARXRARXRB
SCHEMBL7922675 0.91 RARB (0.46) RARBRARGRARARXRABACE1
SCHEMBL1683993 0.91 RARB (0.53) RARBRARGRARARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0879814-B1 Triaromatic compounds, compositions containing them and uses thereof CT INTERNAT DE BR RECH S DERMA (FR) 2001-11-28 EP claimed
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US claimed
JP-11029522-A None JP disclosed
US-6150413-A TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS; 4-(4-(BIPHENYL-2-YL)BUT-3-EN-1-YNYL)BENZOIC ACID, FOR EXAMPLE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 2000-11-21 US disclosed
JP-H1129522-A TRIAROMATIC COMPOUND, COMPOSITION CONTAINING THE SAME AND USE THEREOF CIRD GALDERMA 1999-02-02 JP disclosed