Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 14/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793336 | 0.88 | CYP19A1 (0.45) | CYP11B2CYP11B1CYP19A1AOC3 | |
| SCHEMBL15466773 | 0.83 | CYP11B2 (0.47) | CYP11B2CYP11B1AOC3 | |
| SCHEMBL793824 | 0.82 | CYP11B2 (0.46) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL793106 | 0.81 | CYP11B2 (0.48) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL807995 | 0.80 | CYP11B2 (0.42) | CYP11B2CYP11B1 | |
| SCHEMBL807968 | 0.79 | F10 (0.41) | — | |
| SCHEMBL793208 | 0.79 | CYP19A1 (0.44) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL793461 | 0.78 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL798870 | 0.78 | CYP11B2 (0.47) | CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL807794 | 0.77 | KMT2A (0.51) | CYP11B2CYP11B1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627648-A1 | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS | Novartis AG (CH) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012035078-A1 | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |