Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060648 | 0.90 | CETP (0.46) | CETPCNR2MEN1KMT2AHSD17B10 | |
| SCHEMBL5057932 | 0.88 | CETP (0.44) | CETPCNR2HSD17B10 | |
| SCHEMBL5054584 | 0.86 | FOLH1 (0.39) | CETPCNR2MEN1KMT2AMAPT | |
| SCHEMBL7928565 | 0.85 | POLB (0.39) | CETPCNR2MEN1KMT2AHSD17B10 | |
| SCHEMBL5054814 | 0.83 | CETP (0.38) | CETPCNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL5053178 | 0.83 | FFAR4 (0.43) | CETPMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5052918 | 0.82 | SLC1A3 (0.45) | ACE | |
| SCHEMBL5054249 | 0.81 | FOLH1 (0.46) | MAPK1SMN1; SMN2 | |
| SCHEMBL5054487 | 0.81 | MEN1 (0.42) | CETPCNR2MEN1KMT2AALDH1A1 | |
| SCHEMBL5058025 | 0.81 | FOLH1 (0.41) | CETPMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | claimed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | claimed |