Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929239 | 0.85 | CETP (0.42) | MMEMEN1KMT2ACETPCNR2 | |
| SCHEMBL5054496 | 0.85 | CETP (0.40) | CETPCNR2 | |
| SCHEMBL5054814 | 0.84 | CETP (0.38) | MEN1KMT2ACETPCNR2ACE | |
| SCHEMBL5060648 | 0.83 | CETP (0.46) | MEN1KMT2ACETPCNR2HSD17B10 | |
| SCHEMBL5057863 | 0.83 | GRM8 (0.42) | KMT2A | |
| SCHEMBL5057932 | 0.82 | CETP (0.44) | CETPCNR2HSD17B10 | |
| SCHEMBL7928559 | 0.81 | POLB (0.39) | POLBMMEMEN1KMT2ACETP | |
| SCHEMBL5057891 | 0.81 | ACP3 (0.41) | KMT2ACETPCNR2 | |
| SCHEMBL5054584 | 0.80 | FOLH1 (0.39) | MEN1KMT2ACETPCNR2 | |
| SCHEMBL5054326 | 0.77 | MMP1 (0.38) | TRPA1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | claimed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | claimed |