Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGH | Q92820 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 2/20 | 0.35 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CPA3 | P15088 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059951 | 0.84 | GGH (0.39) | GGHFOLH1ALDH1A1TDP1ACP3 | |
| SCHEMBL8427721 | 0.84 | GGH (0.39) | GGHFOLH1ALDH1A1TDP1ACP3 | |
| SCHEMBL5054411 | 0.78 | GGH (0.43) | GGHFOLH1ALDH1A1CYP1A2 | |
| SCHEMBL5053258 | 0.78 | PLA2G2D (0.43) | FOLH1 | |
| SCHEMBL8457126 | 0.76 | GGH (0.44) | GGHFOLH1ALDH1A1NAALAD2CYP1A2 | |
| SCHEMBL5051300 | 0.75 | GGH (0.45) | GGHFOLH1ALDH1A1TDP1NAALAD2 | |
| SCHEMBL5053300 | 0.74 | GGH (0.39) | GGHFOLH1ALDH1A1TDP1NAALAD2 | |
| SCHEMBL5051319 | 0.73 | FOLH1 (0.51) | FOLH1NAALAD2CPA3 | |
| SCHEMBL5060196 | 0.73 | CPA3 (0.44) | GGHFOLH1ACP3CYP2D6CPA3 | |
| SCHEMBL5051035 | 0.72 | GGH (0.65) | GGHFOLH1NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994707-A4 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2001-11-14 | — | — | EP | claimed |
| EP-0994707-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998053812-A1 | INHIBITORS OF NAALADASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-03 | — | — | WO | claimed |