⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18626026 | 1.00 | — | — | |
| SCHEMBL23009701 | 0.86 | — | — | |
| SCHEMBL1557333 | 0.84 | GRIN1 (0.35) | — | |
| SCHEMBL23009428 | 0.83 | — | — | |
| SCHEMBL1555859 | 0.82 | GRIN1 (0.32) | — | |
| SCHEMBL21225285 | 0.80 | FKBP5 (0.34) | — | |
| SCHEMBL22975111 | 0.80 | FKBP5 (0.34) | — | |
| SCHEMBL21225657 | 0.80 | FKBP5 (0.34) | — | |
| SCHEMBL21225659 | 0.80 | FKBP5 (0.34) | — | |
| Hydrochloric Acid SCHEMBL15012202 | 0.80 | GRIN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250186392-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY HONG KONG CO LTD (HK) | 2025-06-12 | — | — | US | disclosed |
| US-20220273629-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH ELEVATED LEVELS OF ANTIBODIES THAT INTERACT WITH THE NMDA RECEPTOR | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (HK) | 2022-09-01 | — | — | US | disclosed |
| US-20210332061-A1 | NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. | 2021-10-28 | — | — | US | disclosed |
| US-20210169964-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, AND OTHER DISORDERS | INNOVIVA TRC HOLDINGS LLC | 2021-06-10 | — | — | US | disclosed |
| US-10906913-B2 | NMDA receptor modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2021-02-02 | — | — | US | disclosed |
| EP-3679931-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, AND OTHER DISORDERS | Northwestern University (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3564256-A1 | NMDA RECEPTOR MODULATORS | Naurex Inc. (US) | 2019-11-06 | — | — | EP | disclosed |
| US-10441571-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | APTINYX INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20190135862-A1 | NDMA RECEPTOR MODULATORS AND USES THEREOF | INNOVIVA TRC HOLDINGS LLC | 2019-05-09 | — | — | US | disclosed |
| US-10273239-B2 | Spiro-lactam NMDA receptor modulators and uses thereof | APTINYX INC. (US) | 2019-04-30 | — | — | US | disclosed |
| WO-2014120786-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| US-8673843-B2 | NMDA receptors modulators and uses thereof | NORTHWESTERN UNIVERSITY (US) | 2014-03-18 | — | — | US | disclosed |
| WO-2013063120-A2 | NMDA RECEPTOR MODULATORS AND USES THEREOF | NORTHWESTERN UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |
| US-20130053325-A1 | Secondary Structure Stabilized NMDA Receptor Modulators and Uses Thereof | INNOVIVA TRC HOLDINGS LLC | 2013-02-28 | — | — | US | disclosed |
| US-20130053325-A1 | Secondary Structure Stabilized NMDA Receptor Modulators and Uses Thereof | INNOVIVA TRC HOLDINGS LLC | 2013-02-28 | — | — | US | disclosed |
| US-20130035292-A1 | NMDA Receptors Modulators and Uses Thereof | INNOVIVA TRC HOLDINGS LLC | 2013-02-07 | — | — | US | disclosed |
| US-20110306586-A1 | NMDA Receptor Modulators and Uses Thereof | NAUREX, INC. | 2011-12-15 | — | — | US | disclosed |
| US-20110306586-A1 | NMDA Receptor Modulators and Uses Thereof | NAUREX, INC. | 2011-12-15 | — | — | US | disclosed |
| WO-2011100585-A1 | SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF | MOSKAL JOSEPH (US) | 2011-08-18 | — | — | WO | disclosed |
| WO-2010033757-A1 | NMDA RECEPTOR MODULATORS AND USES THEREOF | NAUREX, INC. (US) | 2010-03-25 | — | — | WO | disclosed |